Ki Summary

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Target

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Ligand

BDBM144730

Substrate/Competitor

n/a

Meas. Tech.

IMAP TR-FRET Assay

Temperature

298.15±n/a K

IC50

7.5±n/a nM

Comments

extracted

Citation

Allen, JR; Frohn, MJ; Harrington, PE; Hu, E; Pickrell, AJ; Rzasa, RM; Sham, KK Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors US Patent US8952037 Publication Date 2/10/2015

More Info.:

Get all data from this article, Assay Method

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Name:

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Synonyms:

Type:

Protein

Mol. Mass.:

88412.52

Organism:

Homo sapiens (Human)

Description:

Q9Y233

Residue:

1055

Sequence:

MASLEEPLAPRPQGPLPAAGDEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAE
RAAPPRPPLSSAGRPSPAGGPGALSARGGGCGWVAARAPLALAFSSRVPSSSPSFFYFWP
PPPPPPPSFLPSSSAFHLPVRLPGREGAAAAAAAGGGGDAGGGGGGGQEAAPLSVPTSSS
HRGGGGSGGGRRRLFLSPALQGLLLPARAGPRPPPPPRLPLGQAARRAGSPGFPGAGPGG
GGQTPRRPQGASFALAAAAALLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLS
LHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQ
RLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGP
ITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGIL
ELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNI
VAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRF
SIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQM
VNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSE
EWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMS
VKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSY
LQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATD
LALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYA
EFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKA
CRDNLSQWEKVIRGEETATWISSPSVAQKAAASED

BDBM144730

n/a

Name

BDBM144730

Synonyms:

US8952037, 113

Type

Small organic molecule

Emp. Form.

C22H24N4O2

Mol. Mass.

376.4516

SMILES

C1[C@@H](C[C@@H]1Oc1nccnc1C1CCOCC1)Nc1ccc2ccccc2n1 |r,wD:3.4,1.19,(-.79,-1.14,;-.39,-2.63,;-1.88,-3.03,;-2.28,-1.54,;-3.61,-.77,;-4.94,-1.54,;-4.94,-3.08,;-6.28,-3.85,;-7.61,-3.08,;-7.61,-1.54,;-6.28,-.77,;-6.28,.77,;-4.94,1.54,;-4.94,3.08,;-6.28,3.85,;-7.61,3.08,;-7.61,1.54,;.94,-3.4,;2.28,-2.63,;2.28,-1.09,;3.61,-.32,;4.94,-1.09,;6.28,-.32,;7.61,-1.09,;7.61,-2.63,;6.28,-3.4,;4.94,-2.63,;3.61,-3.4,)|

Structure