Reaction Details |
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Target | Cytochrome P450 11B1, mitochondrial |
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Ligand | BDBM286237 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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IC50 | 1122±n/a nM |
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Citation | Ali, A; Bennett, DJ; Cai, J; Carswell, E; Cooke, A; Hoyt, SB; Lo, M; London, C; MacLean, J; Park, MK; Ratcliffe, P; Taylor, JA; Whitehead, B; Xiong, Y Imidazopyridyl compounds as aldosterone synthase inhibitors US Patent US9518055 Publication Date 12/13/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 11B1, mitochondrial |
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Name: | Cytochrome P450 11B1, mitochondrial |
Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
Type: | Enzyme |
Mol. Mass.: | 57591.44 |
Organism: | Homo sapiens (Human) |
Description: | P15538 |
Residue: | 503 |
Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
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BDBM286237 |
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n/a |
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Name | BDBM286237 |
Synonyms: | 2-(5-(3-cyclopropyl-6- fluoroimidazo[1,2-a]pyridin-2- yl)pyridin-3-yl)-1,1,1- trifluoropropan-2-ol | US9518055, Example 38 |
Type | Small organic molecule |
Emp. Form. | C18H15F4N3O |
Mol. Mass. | 365.3248 |
SMILES | CC(O)(c1cncc(c1)-c1nc2ccc(F)cn2c1C1CC1)C(F)(F)F |
Structure |
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