Reaction Details |
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Target | Epidermal growth factor receptor [1-973] |
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Ligand | BDBM152774 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In vitro EGFR TK Inhibition Assays |
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Temperature | 298.15±n/a K |
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IC50 | 84.8±4.23 nM |
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Comments | extracted |
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Citation | Hu, M; Ye, W; Li, J; Zhong, G; He, G; Xu, Q; Zhang, Y Synthesis and evaluation of salicylanilide derivatives as potential epidermal growth factor receptor inhibitors. Chem Biol Drug Des85:280-9 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Epidermal growth factor receptor [1-973] |
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Name: | Epidermal growth factor receptor [1-973] |
Synonyms: | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) | HER1 | Receptor tyrosine-protein kinase erbB-1 |
Type: | Protein |
Mol. Mass.: | 108055.41 |
Organism: | Homo sapiens (Human) |
Description: | P00533[1-973] |
Residue: | 973 |
Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMAR
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BDBM152774 |
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n/a |
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Name | BDBM152774 |
Synonyms: | 4-(3-Morpholinopropoxy)-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide (13a) |
Type | Small organic molecule |
Emp. Form. | C20H22ClN3O6 |
Mol. Mass. | 435.858 |
SMILES | Oc1cc(OCCCN2CCOCC2)ccc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O |
Structure |
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