Reaction Details | |||
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Target | Beta-secretase 1 | ||
Ligand | BDBM155126 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | TR-FRET Assay | ||
pH | 2.5±n/a | ||
IC50 | 39±n/a nM | ||
Comments | extracted | ||
Citation | Karlstrom, S; Soderman, P; Rakos, L; Ohberg, L; Kolmodin, K; Sandberg, L Cyclohexane-1,2′-indene-1′,2″-imidazol compounds and their use as BACE inhibitors US Patent US9000183 Publication Date 4/7/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Beta-secretase 1 | |||
Name: | Beta-secretase 1 | ||
Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) | ||
Type: | Protein | ||
Mol. Mass.: | 55755.10 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P56817 | ||
Residue: | 501 | ||
Sequence: |
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BDBM155126 | |||
n/a | |||
Name | BDBM155126 | ||
Synonyms: | US9000183, 10 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H27F2N3O2 | ||
Mol. Mass. | 391.4548 | ||
SMILES | CO[C@H]1CC[C@@]2(Cc3cc(F)c(OCCCF)cc3C22N=C(C)C(N)=N2)CC1 |r,wD:5.5,2.1,c:26,t:22,(8.55,-3.04,;7.78,-1.7,;6.24,-1.7,;5.47,-.37,;3.93,-.37,;3.16,-1.7,;2.25,-2.95,;.79,-2.47,;-.55,-3.24,;-1.88,-2.47,;-3.21,-3.24,;-1.88,-.93,;-3.21,-.16,;-4.55,-.93,;-5.88,-.16,;-7.21,-.93,;-8.55,-.16,;-.55,-.16,;.79,-.93,;2.25,-.46,;1.01,.45,;1.48,1.91,;.71,3.24,;3.02,1.91,;3.79,3.24,;3.5,.45,;3.93,-3.04,;5.47,-3.04,)| | ||
Structure |