Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Lipopolysaccharide-induced tumor necrosis factor-alpha factor | ||
| Ligand | BDBM235370 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | TNF inhibition assay | ||
| IC50 | 0.900±n/a nM | ||
| Citation |  Mjalli, AM; Gaddam, B; Polisetti, DR; Kostura, MJ; Guzel, M Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors US Patent US10085990 Publication Date 10/2/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Lipopolysaccharide-induced tumor necrosis factor-alpha factor | |||
| Name: | Lipopolysaccharide-induced tumor necrosis factor-alpha factor | ||
| Synonyms: | LITAF | LITAF_HUMAN | LPS-induced TNF-alpha factor | PIG7 | SIMPLE | Small integral membrane protein of lysosome/late endosome | TNF-alpha | p53-induced gene 7 protein | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 17106.57 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | TNF-alpha 0 HUMAN::Q99732 | ||
| Residue: | 161 | ||
| Sequence: |
| ||
| BDBM235370 | |||
| n/a | |||
| Name | BDBM235370 | ||
| Synonyms: | US10085990, Example 100 | US9393245, 100 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H24ClN3O3 | ||
| Mol. Mass. | 449.929 | ||
| SMILES | COc1cccc2c1ncc1c2n(C2CCC(C)CC2)c(=O)n(-c2ccc(Cl)cc2)c1=O |(-5.33,-5,;-4,-4.23,;-4,-2.69,;-5.33,-1.93,;-5.33,-.38,;-4,.38,;-2.67,-.38,;-2.67,-1.93,;-1.33,-2.69,;,-1.93,;,-.38,;-1.33,.38,;-1.33,1.93,;-2.67,2.69,;-2.67,4.23,;-4,5,;-5.33,4.23,;-6.67,5,;-5.33,2.69,;-4,1.93,;,2.69,;,4.23,;1.33,1.93,;2.67,2.69,;4,1.93,;5.33,2.69,;5.33,4.23,;6.67,5,;4,5,;2.67,4.23,;1.33,.38,;2.67,-.38,)| | ||
| Structure | 
| ||