| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM166439 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition assay |
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| pH | 7.5±n/a |
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| IC50 | 338220±n/a nM |
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| Comments | extracted |
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| Citation |  Hsieh, P; Hwang, T; Wang, W; Wang, T Oxime-based compound, pharmaceutical composition containing the same and method for preparing the same US Patent US9073833 Publication Date 7/7/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM166439 |
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| n/a |
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| Name | BDBM166439 |
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| Synonyms: | US9073833, Sivelestat |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N2O7S |
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| Mol. Mass. | 434.463 |
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| SMILES | CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(O)=NCC(O)=O |w:25.27| |
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| Structure | 
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