| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 [T157A,D319N] |
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| Ligand | BDBM176672 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Quenching Assay |
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| Kd | 6400±300 nM |
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| Citation |  Shapiro, PS; MacKerell, Jr., AD; Fletcher, S Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK) US Patent US9115122 Publication Date 8/25/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 1 [T157A,D319N] |
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| Name: | Mitogen-activated protein kinase 1 [T157A,D319N] |
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| Synonyms: | ERK2(T157A/D319N) | Erk2 | MK01_MOUSE | Mapk | Mapk1 | Prkm1 |
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| Type: | n/a |
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| Mol. Mass.: | 41248.65 |
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| Organism: | Mus musculus (mouse) |
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| Description: | P63085[T157A,D319N] |
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| Residue: | 358 |
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| Sequence: | MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQ
TYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLS
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNATCDLKICDFGLARVADPDHDHTG
FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG
ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI
EVEQALAHPYLEQYYDPSNEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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| BDBM176672 |
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| n/a |
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| Name | BDBM176672 |
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| Synonyms: | US9115122, 76 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16N2O2S2 |
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| Mol. Mass. | 308.419 |
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| SMILES | CCOc1ccc(\C=C2/SC(=S)N(CCN)C2=O)cc1 |
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| Structure | 
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