Reaction Details | |||
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Target | Tyrosine-protein kinase SYK | ||
Ligand | BDBM177762 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 278±n/a nM | ||
Comments | extracted | ||
Citation | Altman, MD; Di Francesco, ME; Haidle, AM; Otte, RD; Ellis, JM; Childers, KK; Northrup, AB; Wang, L Pyridyl aminopyridines as Syk inhibitors US Patent US9120785 Publication Date 9/1/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase SYK | |||
Name: | Tyrosine-protein kinase SYK | ||
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
Type: | Enzyme | ||
Mol. Mass.: | 72079.99 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P43405 | ||
Residue: | 635 | ||
Sequence: |
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BDBM177762 | |||
n/a | |||
Name | BDBM177762 | ||
Synonyms: | US9120785, Example 9 Enantiomer 1 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H35FN4O3S | ||
Mol. Mass. | 526.666 | ||
SMILES | CCCCOC(=O)[C@H]1CC[C@@H](CC1)[C@@](C)(O)c1ncc(s1)-c1cc(C)cc(Nc2cc(C)c(F)cn2)n1 |r,wU:13.14,7.6,wD:13.15,10.10,(8.57,19.44,;7.08,19.84,;5.99,18.75,;4.51,19.15,;3.42,18.06,;1.93,18.46,;1.53,19.95,;.84,17.37,;1.24,15.88,;.15,14.79,;-1.34,15.19,;-1.74,16.68,;-.65,17.77,;-2.11,13.86,;-3.44,14.63,;-3.44,13.09,;-1.34,12.53,;.2,12.53,;.68,11.06,;-.57,10.16,;-1.81,11.06,;-.57,8.62,;.77,7.85,;.77,6.31,;2.1,5.54,;-.57,5.54,;-1.9,6.31,;-3.23,5.54,;-4.57,6.31,;-4.57,7.85,;-5.9,8.62,;-5.9,10.16,;-7.24,7.85,;-8.57,8.62,;-7.24,6.31,;-5.9,5.54,;-1.9,7.85,)| | ||
Structure |