Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase SYK

Ligand

BDBM177767

Substrate/Competitor

n/a

Meas. Tech.

Homogeneous Time-Resolved Fluorescence (HTRF) Assay

7.5±n/a

Temperature

298.15±n/a K

IC50

0.5±n/a nM

Comments

extracted

Citation

Altman, MD; Di Francesco, ME; Haidle, AM; Otte, RD; Ellis, JM; Childers, KK; Northrup, AB; Wang, L Pyridyl aminopyridines as Syk inhibitors US Patent US9120785 Publication Date 9/1/2015

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase SYK

Name:

Tyrosine-protein kinase SYK

Synonyms:

KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)

Type:

Enzyme

Mol. Mass.:

72079.99

Organism:

Homo sapiens (Human)

Description:

P43405

Residue:

635

Sequence:

MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN

BDBM177767

n/a

Name

BDBM177767

Synonyms:

US9120785, Example 14-4

Type

Small organic molecule

Emp. Form.

C24H26F2N4O3S

Mol. Mass.

488.55

SMILES

Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1cnc(s1)C(C)(O)C1CCC(CC1)C(O)=O |(-2.34,-8.32,;-3.67,-7.55,;-5.01,-8.32,;-6.34,-7.55,;-7.67,-8.32,;-9.01,-7.55,;-9.01,-6.01,;-10.34,-5.19,;-11.67,-6.01,;-11.67,-7.55,;-10.34,-8.32,;-10.34,-3.65,;-11.67,-2.88,;-9.01,-2.88,;-6.34,-6.01,;-5.01,-5.24,;-3.67,-6.01,;-5.01,-3.7,;-6.25,-2.8,;-5.78,-1.33,;-4.24,-1.33,;-3.76,-2.8,;-3.47,,;-4.55,1.09,;-2.7,1.33,;-1.93,,;-1.15,-1.33,;.38,-1.33,;1.21,,;.38,1.33,;-1.15,1.33,;2.75,0,;3.52,-1.33,;3.52,1.33,)|

Structure