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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase SYK | ||
| Ligand | BDBM177769 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 0.5±n/a nM | ||
| Comments | extracted | ||
| Citation |  Altman, MD; Di Francesco, ME; Haidle, AM; Otte, RD; Ellis, JM; Childers, KK; Northrup, AB; Wang, L Pyridyl aminopyridines as Syk inhibitors US Patent US9120785 Publication Date 9/1/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase SYK | |||
| Name: | Tyrosine-protein kinase SYK | ||
| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 72079.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P43405 | ||
| Residue: | 635 | ||
| Sequence: |
| ||
| BDBM177769 | |||
| n/a | |||
| Name | BDBM177769 | ||
| Synonyms: | US9120785, Example 14-15 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H27F3N4O3S | ||
| Mol. Mass. | 520.567 | ||
| SMILES | CCC(O)(C1CCC(CC1)C(O)=O)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)C(F)(F)F)n1 |(-6.13,,;-4.8,.77,;-3.47,,;-2.7,1.33,;-1.93,,;-1.15,-1.33,;.38,-1.33,;1.21,,;.38,1.33,;-1.15,1.33,;2.75,0,;3.52,-1.33,;3.52,1.33,;-4.24,-1.33,;-5.78,-1.33,;-6.25,-2.8,;-5.01,-3.7,;-3.76,-2.8,;-5.01,-5.24,;-3.67,-6.01,;-3.67,-7.55,;-2.34,-8.32,;-5.01,-8.32,;-6.34,-7.55,;-7.67,-8.32,;-9.01,-7.55,;-9.01,-6.01,;-10.34,-5.19,;-11.67,-6.01,;-11.67,-7.55,;-10.34,-8.32,;-10.34,-3.65,;-11.67,-2.88,;-10.34,-2.11,;-9.01,-2.88,;-6.34,-6.01,)| | ||
| Structure | 
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