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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM186083
Substrate/Competitorn/a
Meas. Tech.Scintillation Proximity Assay
Temperature298.15±n/a K
IC50 1.54±n/a nM
Commentsextracted
Citation Claremon, DATice, CMZhuang, LLeftheris, KYe, YSingh, SB Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 US Patent US9163012 Publication Date 10/20/2015
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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BDBM186083
n/a
NameBDBM186083
Synonyms:US9163012, 1
TypeSmall organic molecule
Emp. Form.C21H25F2N3O4
Mol. Mass.421.4377
SMILESNC(=O)[C@@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](C1)Oc1ncc(F)cc1F)C(C3)C2 |r,wU:9.10,16.19,wD:3.2,TLB:6:7:29:4.5.28,6:5:29:7.9.8,THB:9:7:4:29.27.28,9:27:4:7.6.8,10:9:29:4.5.28,(-7.63,-22.85,;-6.3,-23.62,;-6.3,-25.16,;-4.97,-22.85,;-5.8,-24.76,;-4.4,-24.11,;-3.2,-24.78,;-2.3,-22.85,;-3.63,-23.63,;-2.3,-21.31,;-.97,-20.54,;.36,-21.32,;.36,-22.86,;1.7,-20.55,;1.7,-19.01,;3.16,-18.53,;4.07,-19.78,;3.16,-21.02,;5.61,-19.78,;6.38,-18.44,;7.87,-18.84,;8.95,-17.75,;8.56,-16.26,;9.64,-15.18,;7.07,-15.87,;5.98,-16.95,;4.49,-16.56,;-3.63,-20.55,;-4.39,-21.71,;-4.97,-21.31,)|
Structure
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