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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM186083 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Scintillation Proximity Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1.54±n/a nM | ||
| Comments | extracted | ||
| Citation |  Claremon, DA; Tice, CM; Zhuang, L; Leftheris, K; Ye, Y; Singh, SB Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 US Patent US9163012 Publication Date 10/20/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
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| BDBM186083 | |||
| n/a | |||
| Name | BDBM186083 | ||
| Synonyms: | US9163012, 1 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H25F2N3O4 | ||
| Mol. Mass. | 421.4377 | ||
| SMILES | NC(=O)[C@@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](C1)Oc1ncc(F)cc1F)C(C3)C2 |r,wU:9.10,16.19,wD:3.2,TLB:6:7:29:4.5.28,6:5:29:7.9.8,THB:9:7:4:29.27.28,9:27:4:7.6.8,10:9:29:4.5.28,(-7.63,-22.85,;-6.3,-23.62,;-6.3,-25.16,;-4.97,-22.85,;-5.8,-24.76,;-4.4,-24.11,;-3.2,-24.78,;-2.3,-22.85,;-3.63,-23.63,;-2.3,-21.31,;-.97,-20.54,;.36,-21.32,;.36,-22.86,;1.7,-20.55,;1.7,-19.01,;3.16,-18.53,;4.07,-19.78,;3.16,-21.02,;5.61,-19.78,;6.38,-18.44,;7.87,-18.84,;8.95,-17.75,;8.56,-16.26,;9.64,-15.18,;7.07,-15.87,;5.98,-16.95,;4.49,-16.56,;-3.63,-20.55,;-4.39,-21.71,;-4.97,-21.31,)| | ||
| Structure | 
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