| Reaction Details |
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 | Report a problem with these data |
| Target | Thyrotropin receptor |
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| Ligand | BDBM60853 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Antagonist Activity Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Karstens, WF; Conti, PG; Timmers, CM; Plate, R; Van Koppen, CJ TSH receptor antagonizing tetrahydroquinoline compounds US Patent US9174940 Publication Date 11/3/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyrotropin receptor |
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| Name: | Thyrotropin receptor |
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| Synonyms: | LGR3 | TSH-R | TSHR | TSHR_HUMAN | Thyroid stimulating hormone receptor | Thyroid-stimulating hormone receptor | Thyroid-stimulating hormone receptor (TSH) | Thyrotropin receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 86834.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P16473 |
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| Residue: | 764 |
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| Sequence: | MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLI
ETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPD
ALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETL
TLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTA
LPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLM
CNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQE
DEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIV
VWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSE
YYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACA
IMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCC
YVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSK
ILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQ
VQKVTHDMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
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| BDBM60853 |
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| n/a |
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| Name | BDBM60853 |
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| Synonyms: | US9174940, 27 |
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| Type | n/a |
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| Emp. Form. | C24H30N2O3 |
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| Mol. Mass. | 394.5066 |
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| SMILES | CC(C)CCOC(=O)Nc1ccc2N(CCC(C)(c3ccccc3)c2c1)C(C)=O |
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| Structure | 
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