Reaction Details |
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Target | Thyrotropin receptor |
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Ligand | BDBM60863 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Antagonist Activity Assay |
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IC50 | <100±n/a nM |
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Citation | Karstens, WF; Conti, PG; Timmers, CM; Plate, R; Van Koppen, CJ TSH receptor antagonizing tetrahydroquinoline compounds US Patent US9174940 Publication Date 11/3/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Thyrotropin receptor |
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Name: | Thyrotropin receptor |
Synonyms: | LGR3 | TSH-R | TSHR | TSHR_HUMAN | Thyroid stimulating hormone receptor | Thyroid-stimulating hormone receptor | Thyroid-stimulating hormone receptor (TSH) | Thyrotropin receptor |
Type: | Enzyme |
Mol. Mass.: | 86834.44 |
Organism: | Homo sapiens (Human) |
Description: | P16473 |
Residue: | 764 |
Sequence: | MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLI
ETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPD
ALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETL
TLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTA
LPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLM
CNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQE
DEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIV
VWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSE
YYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACA
IMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCC
YVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSK
ILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQ
VQKVTHDMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
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BDBM60863 |
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n/a |
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Name | BDBM60863 |
Synonyms: | US9174940, 33 |
Type | n/a |
Emp. Form. | C30H31F3N2O2 |
Mol. Mass. | 508.5745 |
SMILES | CC(=O)N1c2ccc(NC(=O)CCc3cccc(c3)C(F)(F)F)cc2C(C)(CC1(C)C)c1ccccc1 |
Structure |
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