| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-glucuronidase |
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| Ligand | BDBM193665 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | β-Glucuronidase assay |
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| IC50 | 5.925e+4± 1.20e+3 nM |
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| Citation |  Taha, M; Ismail, NH; Imran, S; Wadood, A; Rahim, F; Al Muqarrabin, LM; Zaki, HM; Ahmat, N; Nasir, A; Khan, F Synthesis of novel disulfide and sulfone hybrid scaffolds as potent ß-glucuronidase inhibitor. Bioorg Chem68:15-22 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-glucuronidase |
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| Name: | Beta-glucuronidase |
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| Synonyms: | Beta-glucuronidase | Beta-glucuronidase (β-glucuronidase) | EMBL:AAI33416.1 | Ensembl:ENSBTAP00000000941 | Ensembl:ENSBTAP00000000941} | GUSB |
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| Type: | Protein |
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| Mol. Mass.: | 74467.69 |
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| Organism: | Bos taurus (Bovine) |
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| Description: | EC 3.2.1.31, bovine liver |
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| Residue: | 652 |
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| Sequence: | MLRGSAGAWAVLGPLLWGCGLSLLQGGMLYPRESRSRERKELDGLWSFRADFSDNRRQGF
EQQWYRAPLRESGPTLDMPVPSSFNDVGQDGQLRSFVGWVWYEREITLPQRWTEDLGTRV
VLRIGSAHYYAIVWVNGVHVLEHEGGHLPFEADISKLVQSGPLSSCRITIAINNTLSPHT
LPPGTILYKTDPSMYPKGYFVQNTKFDFFNYAGLHRSVLLYTTPTTYIDDITVTTDMDQD
IGLVNYQIIVQGSDHFQVDVSLLDEEGKVMAKGAGAEGQLQVPSAHLWWPYLMHEHPAYL
YSLEVKLTAQTAVGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFRGVNKHEDADIRGKG
FDWPLLVKDFNLLRWLGANAFRTSHYPYSEEVLQLCDRYGIVVIDESPGVGIVLVESFSN
VSLQHHLEVMEEMIRRDKNHPAVVMWSLANEPASFLKPAGYYFKTLIAHTKALDPSRPVT
FVTNTNYEADLGAPYVDIICVNSYYSWYHDYGHMEVIQLQLATQFENWYKAYQKPMIQSE
YGADAIEGFHEDPPLMFSEEYQKGLLQQYHVVLDQKRKEYVVGELIWNFADFMTNQSPVR
MIGNRKGIFTRQRQPKSAAFLLRERYWKLANETRYQRSAVTSQCVGSGLFTV
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| BDBM193665 |
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| n/a |
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| Name | BDBM193665 |
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| Synonyms: | N,N'-(disulfanediylbis(2,1-phenylene))bis(3-nitrobenzenesulfonamide) (12) |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18N4O8S4 |
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| Mol. Mass. | 618.682 |
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| SMILES | [O-][N+](=O)c1cccc(c1)S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1cccc(c1)[N+]([O-])=O |
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| Structure | 
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