Reaction Details |
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Target | Hypoxanthine-guanine-xanthine phosphoribosyltransferase |
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Ligand | BDBM60896 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Growth Inhibition Assay |
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Temperature | 310.15±n/a K |
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Ki | 2600±400 nM |
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Comments | extracted |
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Citation | De Jersey, J; Guddat, LW; Hockova, D; Keough, DT 6-oxopurine phosphoribosyltransferase inhibitors US Patent US9200020 Publication Date 12/1/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Hypoxanthine-guanine-xanthine phosphoribosyltransferase |
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Name: | Hypoxanthine-guanine-xanthine phosphoribosyltransferase |
Synonyms: | HGXR_PLAFG | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) | Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT) | LACZ |
Type: | Protein |
Mol. Mass.: | 26352.14 |
Organism: | Plasmodium falciparum |
Description: | P20035 |
Residue: | 231 |
Sequence: | MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYD
IKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQ
STGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPL
WNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL
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BDBM60896 |
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n/a |
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Name | BDBM60896 |
Synonyms: | US9200020, Table 3 compound 10B |
Type | n/a |
Emp. Form. | C11H19N5O5P |
Mol. Mass. | 332.2728 |
SMILES | OCCN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O |
Structure |
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