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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Solute carrier family 22 member 12 | ||
| Ligand | BDBM37953 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | xanthine oxidase activity | ||
| IC50 | 52500±5900 nM | ||
| Citation |  Warrell, Jr., RP; Piwinski, JJ Bifunctional compounds and use for reducing uric acid levels US Patent US10093658 Publication Date 10/9/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Solute carrier family 22 member 12 | |||
| Name: | Solute carrier family 22 member 12 | ||
| Synonyms: | OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 59638.65 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q96S37 | ||
| Residue: | 553 | ||
| Sequence: |
| ||
| BDBM37953 | |||
| n/a | |||
| Name | BDBM37953 | ||
| Synonyms: | US10093631, Compound Lesinurad | US10336710, Lesinurad | US10752613, Compound Lesinurad | US11020397, Compound Lesinurad | US11149013, Compound lesinurad | US11161835, Compound Lesinurad | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H14BrN3O2S | ||
| Mol. Mass. | 404.281 | ||
| SMILES | OC(=O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12 |(-2.97,1.02,;-1.83,-.01,;-2.15,-1.52,;-.36,.46,;-.04,1.97,;1.42,2.45,;1.9,3.91,;3.44,3.91,;3.91,2.45,;5.38,1.97,;2.67,1.54,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;2.67,-4.62,;3.44,-5.95,;1.9,-5.95,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;6.67,-.77,;5.33,,;4,-.77,)| | ||
| Structure | 
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