| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein-glutamine gamma-glutamyltransferase 2 |
|---|
| Ligand | BDBM204889 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TGM2 Inhibitory Activity Assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 1400±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Szillat, H; Leeuw, T; Lorenz, M Isothiazolopyridine-2-carboxamides and their use as pharmaceuticals US Patent US9260454 Publication Date 2/16/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein-glutamine gamma-glutamyltransferase 2 |
|---|
| Name: | Protein-glutamine gamma-glutamyltransferase 2 |
|---|
| Synonyms: | Protein-glutamine gamma-glutamyltransferase | Protein-glutamine gamma-glutamyltransferase 2 (TG2) | TGM2 | TGM2_HUMAN | Tissue transglutaminase | Tissue transglutaminase (TG2) | Transglutaminase 2 (TGM2) | Transglutaminase C | Transglutaminase-2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 77309.30 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P21980 |
|---|
| Residue: | 687 |
|---|
| Sequence: | MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFS
VVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLE
ASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPW
NFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGR
WDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTN
YNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPT
PQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSL
IVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVG
QSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEK
SVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQK
RKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMG
LHKLVVNFESDKLKAVKGFRNVIIGPA
|
|
|
|---|
| BDBM204889 |
|---|
| n/a |
|---|
| Name | BDBM204889 |
|---|
| Synonyms: | US9260454, 22 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H23N3O11S |
|---|
| Mol. Mass. | 525.486 |
|---|
| SMILES | CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@H](NC(=O)n2sc3ncccc3c2=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
