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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM209564 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <10±n/a nM | ||
| Comments | extracted | ||
| Citation |  Kim, D; Bok, J; Shin, S Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme US Patent US9271969 Publication Date 3/1/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
| ||
| BDBM209564 | |||
| n/a | |||
| Name | BDBM209564 | ||
| Synonyms: | US9271969, 52 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H24F3N3O4S | ||
| Mol. Mass. | 543.557 | ||
| SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1cn2cc(nc2s1)C(=O)Nc1cccc(OC(F)(F)F)c1 |r,wU:7.10,wD:4.3,(12.35,2,;10.88,2,;10.11,3.33,;10.11,.67,;8.57,.67,;7.8,2,;6.26,2,;5.49,.67,;6.26,-.67,;7.8,-.67,;3.95,.67,;3.18,-.67,;1.64,-.67,;.87,.67,;1.64,2,;3.18,2,;-.67,.67,;-1.58,-.58,;-3.05,-.1,;-4.51,-.58,;-5.41,.67,;-4.51,1.91,;-3.05,1.44,;-1.58,1.91,;-6.96,.67,;-7.73,2,;-7.73,-.67,;-9.27,-.67,;-10.04,.67,;-11.58,.67,;-12.35,-.67,;-11.58,-2,;-12.35,-3.33,;-13.89,-3.33,;-15.43,-3.33,;-13.89,-4.87,;-13.49,-1.85,;-10.04,-2,)| | ||
| Structure | 
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