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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM209566 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <10±n/a nM | ||
| Comments | extracted | ||
| Citation |  Kim, D; Bok, J; Shin, S Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme US Patent US9271969 Publication Date 3/1/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM209566 | |||
| n/a | |||
| Name | BDBM209566 | ||
| Synonyms: | US9271969, 54 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H27F2N3O3S | ||
| Mol. Mass. | 535.605 | ||
| SMILES | OC(=O)C[C@H]1CCC(CC1)c1ccc(cc1)-c1cn2cc(nc2s1)C(=O)NC1(CC1)c1cc(F)ccc1F |r,wD:4.3,(11.61,2.67,;10.07,2.67,;9.3,4,;9.3,1.33,;7.76,1.33,;6.99,2.67,;5.45,2.67,;4.68,1.33,;5.45,,;6.99,,;3.14,1.33,;2.37,,;.83,,;.06,1.33,;.83,2.67,;2.37,2.67,;-1.48,1.33,;-2.39,.09,;-3.85,.56,;-5.31,.09,;-6.22,1.33,;-5.31,2.58,;-3.85,2.1,;-2.39,2.58,;-7.76,1.33,;-8.53,2.67,;-8.53,,;-10.07,,;-10.84,1.33,;-11.61,,;-9.3,-1.33,;-7.76,-1.33,;-6.99,-2.67,;-5.45,-2.67,;-7.76,-4,;-9.3,-4,;-10.07,-2.67,;-11.61,-2.67,)| | ||
| Structure | 
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