Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM209526 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | <1.0±n/a nM | ||
Comments | extracted | ||
Citation | Kim, D; Bok, J; Shin, S Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme US Patent US9271969 Publication Date 3/1/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Enzyme | ||
Mol. Mass.: | 56810.61 | ||
Organism: | Mus musculus (mouse) | ||
Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
Residue: | 498 | ||
Sequence: |
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BDBM209526 | |||
n/a | |||
Name | BDBM209526 | ||
Synonyms: | US9271969, 14 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H29N3O5 | ||
Mol. Mass. | 511.5684 | ||
SMILES | OC(=O)C[C@H]1CCC(CC1)c1ccc(cc1)-c1ccc2nc(cn2c1)C(=O)NCc1ccc2OCOc2c1 |r,wD:4.3,(12.82,-6.32,;11.49,-5.55,;11.49,-4.01,;10.15,-6.32,;8.82,-5.55,;8.82,-4.01,;7.48,-3.24,;6.15,-4.01,;6.15,-5.55,;7.48,-6.32,;4.82,-3.24,;3.48,-4.01,;2.15,-3.24,;2.15,-1.7,;3.48,-.93,;4.82,-1.7,;.82,-.93,;.82,.61,;-.52,1.38,;-1.85,.61,;-3.32,1.09,;-4.22,-.16,;-3.32,-1.41,;-1.85,-.93,;-.52,-1.7,;-5.76,-.16,;-6.53,-1.49,;-6.53,1.17,;-8.07,1.17,;-8.84,2.51,;-8.07,3.84,;-8.84,5.18,;-10.38,5.18,;-11.41,6.32,;-12.82,5.69,;-12.66,4.16,;-11.15,3.84,;-10.38,2.51,)| | ||
Structure |