Ki Summary

Reaction Details

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Target

Diacylglycerol O-acyltransferase 1

Ligand

BDBM209538

Substrate/Competitor

n/a

Meas. Tech.

Inhibition Assay

7.4±n/a

Temperature

298.15±n/a K

IC50

9.9±n/a nM

Comments

extracted

Citation

Kim, D; Bok, J; Shin, S Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme US Patent US9271969 Publication Date 3/1/2016

More Info.:

Get all data from this article, Assay Method

Diacylglycerol O-acyltransferase 1

Name:

Diacylglycerol O-acyltransferase 1

Synonyms:

Type:

Enzyme

Mol. Mass.:

56810.61

Organism:

Mus musculus (mouse)

Description:

In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system.

Residue:

498

Sequence:

MGDRGGAGSSRRRRTGSRVSVQGGSGPKVEEDEVRDAAVSPDLGAGGDAPAPAPAPAHTR
DKDGRTSVGDGYWDLRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKY
GILVDPIQVVSLFLKDPYSWPAPCVIIASNIFVVAAFQIEKRLAVGALTEQMGLLLHVVN
LATIICFPAAVALLVESITPVGSVFALASYSIMFLKLYSYRDVNLWCRQRRVKAKAVSTG
KKVSGAAAQQAVSYPDNLTYRDLYYFIFAPTLCYELNFPRSPRIRKRFLLRRVLEMLFFT
QLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWFFHSCLNAV
AELLQFGDREFYRDWWNAESVTYFWQNWNIPVHKWCIRHFYKPMLRHGSSKWVARTGVFL
TSAFFHEYLVSVPLRMFRLWAFTAMMAQVPLAWIVGRFFQGNYGNAAVWVTLIIGQPVAV
LMYVHDYYVLNYDAPVGV

BDBM209538

n/a

Name

BDBM209538

Synonyms:

US9271969, 26

Type

Small organic molecule

Emp. Form.

C32H33N3O5

Mol. Mass.

539.6215

SMILES

OC(=O)C[C@H]1CCC(CC1)c1ccc(cc1)-c1ccc2nc(cn2c1)C(=O)NCc1ccc2OCCCOc2c1 |r,wD:4.3,(12.21,-7.42,;10.74,-6.62,;10.74,-5.08,;9.43,-7.3,;8.1,-6.53,;8.1,-4.99,;6.76,-4.22,;5.43,-4.99,;5.43,-6.53,;6.76,-7.3,;4.1,-4.22,;2.76,-4.99,;1.43,-4.22,;1.43,-2.68,;2.76,-1.91,;4.1,-2.68,;.1,-1.91,;.1,-.37,;-1.24,.4,;-2.57,-.37,;-4.04,.11,;-4.94,-1.14,;-4.04,-2.39,;-2.57,-1.91,;-1.24,-2.68,;-6.48,-1.14,;-7.25,-2.47,;-7.25,.19,;-6.48,1.53,;-7.25,2.86,;-6.48,4.19,;-7.25,5.53,;-8.79,5.53,;-9.35,6.96,;-10.83,7.42,;-12.1,6.55,;-12.21,5.01,;-11.09,3.97,;-9.56,4.19,;-8.79,2.86,)|

Structure