Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM209555 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | <10±n/a nM | ||
Comments | extracted | ||
Citation | Kim, D; Bok, J; Shin, S Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme US Patent US9271969 Publication Date 3/1/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Enzyme | ||
Mol. Mass.: | 56810.61 | ||
Organism: | Mus musculus (mouse) | ||
Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
Residue: | 498 | ||
Sequence: |
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BDBM209555 | |||
n/a | |||
Name | BDBM209555 | ||
Synonyms: | US9271969, 43 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H29Cl2N3O3 | ||
Mol. Mass. | 550.476 | ||
SMILES | Cc1cc(Cl)cc(Cl)c1CNC(=O)c1cn2cc(ccc2n1)-c1ccc(cc1)C1CC[C@H](CC(O)=O)CC1 |r,wD:31.35,(-7.37,3.75,;-8.91,3.75,;-9.68,5.08,;-11.22,5.08,;-11.99,6.41,;-11.99,3.75,;-11.22,2.41,;-11.99,1.08,;-9.68,2.41,;-8.91,1.08,;-7.37,1.08,;-6.6,-.25,;-7.37,-1.59,;-5.06,-.25,;-4.15,-1.5,;-2.69,-1.02,;-1.35,-1.79,;-.02,-1.02,;-.02,.52,;-1.35,1.29,;-2.69,.52,;-4.15,.99,;1.32,-1.79,;1.32,-3.33,;2.65,-4.1,;3.98,-3.33,;3.98,-1.79,;2.65,-1.02,;5.32,-4.1,;6.65,-3.33,;7.98,-4.1,;7.98,-5.64,;9.32,-6.41,;10.65,-5.64,;11.99,-6.41,;10.65,-4.1,;6.65,-6.41,;5.32,-5.64,)| | ||
Structure |