Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM209573 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | <10±n/a nM | ||
Comments | extracted | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Enzyme | ||
Mol. Mass.: | 56810.61 | ||
Organism: | Mus musculus (mouse) | ||
Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
Residue: | 498 | ||
Sequence: |
| ||
BDBM209573 | |||
n/a | |||
Name | BDBM209573 | ||
Synonyms: | US9271969, 61 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H25Cl2N3O3S | ||
Mol. Mass. | 542.477 | ||
SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1cn2cc(nc2s1)C(=O)NCc1c(Cl)cccc1Cl |r,wU:7.10,wD:4.3,(12.38,2.67,;10.84,2.67,;10.07,4,;10.07,1.33,;8.53,1.33,;7.76,2.67,;6.22,2.67,;5.45,1.33,;6.22,,;7.76,,;3.91,1.33,;3.14,2.67,;1.6,2.67,;.83,1.33,;1.6,,;3.14,,;-.71,1.33,;-1.62,.09,;-3.08,.56,;-4.54,.09,;-5.45,1.33,;-4.54,2.58,;-3.08,2.1,;-1.62,2.58,;-6.99,1.33,;-7.76,2.67,;-7.76,,;-9.3,,;-10.07,-1.33,;-11.61,-1.33,;-12.38,,;-12.38,-2.67,;-11.61,-4,;-10.07,-4,;-9.3,-2.67,;-7.76,-2.67,)| | ||
Structure | ![]() |