| Reaction Details |
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 | Report a problem with these data |
| Target | Growth hormone secretagogue receptor type 1 [E24Q] |
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| Ligand | BDBM212437 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | GHS Ligand Binding Assay |
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| Ki | 915±0 nM |
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| Citation |  Mary, S; Fehrentz, JA; Damian, M; Gaibelet, G; Orcel, H; Verdié, P; Mouillac, B; Martinez, J; Marie, J; Banères, JL Heterodimerization with Its splice variant blocks the ghrelin receptor 1a in a non-signaling conformation: a study with a purified heterodimer assembled into lipid discs. J Biol Chem288:24656-65 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth hormone secretagogue receptor type 1 [E24Q] |
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| Name: | Growth hormone secretagogue receptor type 1 [E24Q] |
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| Synonyms: | GHSR | GHSR_HUMAN | Ghrelin receptor 1a (GHS-R1a E124Q) |
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| Type: | Protein |
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| Mol. Mass.: | 41334.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human ghrelin receptor 1a E124Q mutant |
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| Residue: | 366 |
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| Sequence: | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSQSCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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| BDBM212437 |
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| n/a |
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| Name | BDBM212437 |
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| Synonyms: | JMV 3011 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H35N7O3 |
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| Mol. Mass. | 625.7189 |
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| SMILES | COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2C(Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)c(OC)c1 |
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| Structure | 
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