Reaction Details |
| Report a problem with these data |
Target | 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 |
---|
Ligand | BDBM213188 |
---|
Substrate/Competitor | BDBM213211 |
---|
Meas. Tech. | In Vitro AMPK Activation Assay |
---|
pH | 7.3±n/a |
---|
EC50 | 10±n/a nM |
---|
Comments | extracted |
---|
Citation | Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Azabenzimidazole hexahydrofuro[3,2-b]furan derivatives US Patent US9290517 Publication Date 3/22/2016 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 |
---|
Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 |
Synonyms: | AMPK alpha2/beta1/gamma1 | AMPK complex 7 (alpha-2,beta-1,gamma-1) | AMPK complex 7 (containing alpha-2, beta-1, gamma-1) |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 1970361 |
Components: | This complex has 3 components. |
Component 1 |
Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
Synonyms: | AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2 |
Type: | Enzyme |
Mol. Mass.: | 62331.02 |
Organism: | Homo sapiens (Human) |
Description: | P54646 |
Residue: | 552 |
Sequence: | MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK
IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF
QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA
APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS
VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF
ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP
PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY
RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR
SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF
EMCASLITTLAR
|
|
|
Component 2 |
Name: | 5'-AMP-activated protein kinase subunit gamma-1 |
Synonyms: | 5'-AMP-activated protein kinase subunit gamma-1 | AAKG1_HUMAN | AMP-activated protein kinase, gamma-1 subunit | AMPK alpha2/beta2/gamma1 | AMPK gamma-1 | AMPK gamma1 | AMPK subunit gamma-1 | AMPKg | PRKAG1 |
Type: | n/a |
Mol. Mass.: | 37581.44 |
Organism: | Homo sapiens (Human) |
Description: | P54619 |
Residue: | 331 |
Sequence: | METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKA
FFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREV
YLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFI
TEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDI
YSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRL
VVVDENDVVKGIVSLSDILQALVLTGGEKKP
|
|
|
Component 3 |
Name: | 5'-AMP-activated protein kinase subunit beta-1 |
Synonyms: | 5'-AMP-activated protein kinase subunit beta-1 | AAKB1_HUMAN | AMP-activated protein kinase alpha-2/beta-1/gamma-3 | AMPK | AMPK subunit beta-1 | AMPKb | PRKAB1 |
Type: | n/a |
Mol. Mass.: | 30380.94 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y478 |
Residue: | 270 |
Sequence: | MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEF
LAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPE
GEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELS
SSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLY
ALSIKDGVMVLSATHRYKKKYVTTLLYKPI
|
|
|
BDBM213188 |
---|
BDBM213211 |
---|
Name | BDBM213188 |
Synonyms: | US9290517, 71 |
Type | Small organic molecule |
Emp. Form. | C25H25ClN4O4 |
Mol. Mass. | 480.943 |
SMILES | O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)C#CC1CCNCC1 |r| |
Structure |
|