Reaction Details | |||
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Target | Sodium channel protein type 9 subunit alpha | ||
Ligand | BDBM217892 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Nav1.7 In Vitro PX Assay | ||
IC50 | 7±n/a nM | ||
Citation | Weiss, M; Boezio, A; Boezio, C; Butler, JR; Chu-Moyer, MY; Dimauro, EF; Dineen, T; Graceffa, R; Guzman-Perez, A; Huang, H; Kreiman, C; La, D; Marx, IE; Milgrim, BC; Nguyen, HN; Peterson, E; Romero, K; Sparling, B Bicyclic sulfonamide compounds as sodium channel inhibitors US Patent US9212182 Publication Date 12/15/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Sodium channel protein type 9 subunit alpha | |||
Name: | Sodium channel protein type 9 subunit alpha | ||
Synonyms: | NENA | Neuroendocrine sodium channel | Peripheral sodium channel 1 | SCN9A | SCN9A_HUMAN | Sodium channel protein type IX alpha subunit | Voltage-gated sodium channel subunit Nav1.7 | Voltage-gated sodium channel subunit alpha Nav1.7 | hNE-Na | ||
Type: | Protein | ||
Mol. Mass.: | 226375.97 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15858 | ||
Residue: | 1988 | ||
Sequence: |
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BDBM217892 | |||
n/a | |||
Name | BDBM217892 | ||
Synonyms: | US9212182, 633 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H21ClFN3O5S | ||
Mol. Mass. | 602.032 | ||
SMILES | COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1ccc(cc1)-c1ccc(Cl)cc1 |(6.67,-5.39,;5.33,-4.62,;4,-5.39,;4,-6.93,;2.67,-7.7,;1.33,-6.93,;,-7.7,;1.33,-5.39,;2.67,-4.62,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;6.67,-.77,;5.33,,;4,-.77,;2.67,,;1.33,-.77,;1.33,-2.31,;,-3.08,;8,,;8.77,-1.33,;7.23,1.33,;9.34,.77,;10.67,,;10.83,-1.53,;12.34,-1.85,;13.11,-.52,;12.08,.63,;2.67,-9.24,;1.33,-10.01,;1.33,-11.55,;2.67,-12.32,;4,-11.55,;4,-10.01,;2.67,-13.86,;1.33,-14.63,;1.33,-16.17,;2.67,-16.94,;2.67,-18.48,;4,-16.17,;4,-14.63,)| | ||
Structure |