| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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| Ligand | BDBM218796 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DELFIA |
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| IC50 | 220±10 nM |
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| Citation |  Barile, E; Marconi, GD; De, SK; Baggio, C; Gambini, L; Salem, AF; Kashyap, MK; Castro, JE; Kipps, TJ; Pellecchia, M hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents. ACS Chem Biol12:444-455 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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| Name: | Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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| Synonyms: | B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L) |
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| Type: | Homodimers/heterodimers with BAX, BAK and BCL2 |
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| Mol. Mass.: | 26053.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_510901 |
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| Residue: | 233 |
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| Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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| BDBM218796 |
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| n/a |
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| Name | BDBM218796 |
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| Synonyms: | 130D11 | Ac-λAQELR(Xi)IGD(Xi+4)FNAYYARR-NH2 |
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| Type | Small organic molecule |
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| Emp. Form. | C109H167ClN32O29 |
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| Mol. Mass. | 2425.142 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@](C)(CCCC=C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(CNC(=O)CCl)NC(C)=O)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CCCC=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| |
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| Structure | 
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