Reaction Details |
| Report a problem with these data |
Target | Casein kinase II subunit alpha/beta |
---|
Ligand | BDBM220059 |
---|
Substrate/Competitor | BDBM220098 |
---|
Meas. Tech. | In Vitro Cell-Free Assay |
---|
pH | 7.2±n/a |
---|
IC50 | <10±n/a nM |
---|
Comments | extracted |
---|
Citation | Haddach, M; Tran, JA; Pierre, F; Regan, CF; Raffaele, N; Ravula, S; Ryckman, DM Pyrazolopyrimidines and related heterocycles as CK2 inhibitors US Patent US9303033 Publication Date 4/5/2016 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Casein kinase II subunit alpha/beta |
---|
Name: | Casein kinase II subunit alpha/beta |
Synonyms: | Casein kinase 2 (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha alpha beta beta | Complex of catalytic (CK2α) and non-catalytic (CK2β) subunits |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 989485 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Casein kinase II subunit alpha |
Synonyms: | CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a) |
Type: | Enzyme |
Mol. Mass.: | 45151.12 |
Organism: | Homo sapiens (Human) |
Description: | P68400 |
Residue: | 391 |
Sequence: | MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD
QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT
PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
|
|
|
Component 2 |
Name: | Casein kinase II subunit beta |
Synonyms: | CK II beta | CSK2B_RAT | Casein kinase II beta | Casein kinase II subunit beta | Ck2n | Csnk2b | Phosvitin |
Type: | PROTEIN |
Mol. Mass.: | 24937.13 |
Organism: | Rattus norvegicus |
Description: | EBI_10969 |
Residue: | 215 |
Sequence: | MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDE
ELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPML
PIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPA
NQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
|
|
|
BDBM220059 |
---|
BDBM220098 |
---|
Name | BDBM220059 |
Synonyms: | US9303033, C48, Table 58A, Compound 26 | US9303033, I49, Table 59A, Compound 19 |
Type | Small organic molecule |
Emp. Form. | C16H11ClFN7O2 |
Mol. Mass. | 387.756 |
SMILES | Nc1cc(Nc2cc(Cl)ccc2F)nc2c(\C=C3/NC(=O)NC3=O)cnn12 |
Structure |
|