Reaction Details |
| Report a problem with these data |
Target | Neuronal acetylcholine receptor subunit alpha-2/beta-2 |
---|
Ligand | BDBM50428079 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | [3H]-Epibatidine Radioligand Binding Assay |
---|
pH | 7.4±n/a |
---|
Temperature | 277.15±n/a K |
---|
Ki | 13±n/a nM |
---|
Comments | extracted |
---|
Citation | Xiao, Y; Kellar, KJ; Brown, ML; Paige, MA; Liu, Y; Levin, ED; Rezvani, AH 2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof US Patent US9303017 Publication Date 4/5/2016 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Neuronal acetylcholine receptor subunit alpha-2/beta-2 |
---|
Name: | Neuronal acetylcholine receptor subunit alpha-2/beta-2 |
Synonyms: | Neuronal acetylcholine receptor protein alpha-2/beta-2 subunit | Neuronal acetylcholine receptor; alpha2/beta2 | nAChR subtypes alpha2 beta2 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 143226 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Neuronal acetylcholine receptor subunit alpha-2 |
Synonyms: | ACHA2_RAT | Acra2 | Cholinergic, Nicotinic Alpha2Beta2 | Cholinergic, Nicotinic Alpha2Beta4 | Chrna2 |
Type: | Enzyme |
Mol. Mass.: | 58597.25 |
Organism: | Rattus norvegicus (Rat) |
Description: | P12389 |
Residue: | 511 |
Sequence: | MTLSHSALQFWTHLYLWCLLLVPAVLTQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDV
VIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNVTSLRVPSEMIWIP
DIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGS
WTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRR
LPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSL
VIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRP
LPPMELHGSPDLKLSPSYHWLETNMDAGEREETEEEEEEEDENICVCAGLPDSSMGVLYG
HGGLHLRAMEPETKTPSQASEILLSPQIQKALEGVHYIADRLRSEDADSSVKEDWKYVAM
VVDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
|
|
|
Component 2 |
Name: | Neuronal acetylcholine receptor subunit beta-2 |
Synonyms: | ACHB2_RAT | Acrb2 | Chrnb2 | N-alpha 1 | Neuronal acetylcholine receptor non-alpha-1 chain |
Type: | Enzyme |
Mol. Mass.: | 56910.32 |
Organism: | Rattus norvegicus (Rat) |
Description: | P12390 |
Residue: | 500 |
Sequence: | MAGHSNSMALFSFSLLWLCSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLM
VSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYN
NADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRT
EIDLVLKSDVASLDDFTPSGEWDIIALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINL
IIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYL
MFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFLQQPRHRCARQRL
RLRRRQREREGAGALFFREGPAADPCTCFVNPASVQGLAGAFRAEPTAAGPGRSVGPCSC
GLREAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTVGMFLQPL
FQNYTATTFLHPDHSAPSSK
|
|
|
BDBM50428079 |
---|
n/a |
---|
Name | BDBM50428079 |
Synonyms: | CHEMBL2323569 | US9303017, 25, YL-1-199 |
Type | Small organic molecule |
Emp. Form. | C15H18N2O |
Mol. Mass. | 242.3162 |
SMILES | Cc1ncc(cc1OC[C@@H]1CCN1)C#CC1CC1 |r| |
Structure |
|