| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin S |
|---|
| Ligand | BDBM225185 |
|---|
| Substrate/Competitor | BDBM225228 |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| IC50 | 2.2±n/a nM |
|---|
| Citation |  Nakajima, Y; Imada, S; Takasuna, Y; Aoyama, N; Nigawara, T; Shirakami, S; Shirai, F; Sato, J; Nakanishi, K; Kubo, K Nitrogen-containing bicyclic aromatic heterocyclic compound US Patent US9328118 Publication Date 5/3/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin S |
|---|
| Name: | Cathepsin S |
|---|
| Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 37507.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25774 |
|---|
| Residue: | 331 |
|---|
| Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
|
|
|
|---|
| BDBM225185 |
|---|
| BDBM225228 |
|---|
| Name | BDBM225185 |
|---|
| Synonyms: | US9328118, 105 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H35F3N6O3 |
|---|
| Mol. Mass. | 596.6432 |
|---|
| SMILES | CN1CCC[C@H]1C(=O)N1CCC(COc2ccc(cc2C(F)(F)F)-c2nc(nc3n(CC4CCOC4)ccc23)C#N)CC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
