| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 [808-1132] |
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| Ligand | BDBM228673 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 0.055±0.055 nM |
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| Comments | extracted |
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| Citation |  Su, W; Deng, W; Li, J; Ji, J Pyrrolopyrimidine compounds and uses thereof US Patent US9346810 Publication Date 5/24/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tyrosine-protein kinase JAK2 [808-1132] |
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| Name: | Tyrosine-protein kinase JAK2 [808-1132] |
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| Synonyms: | JAK2 | JAK2_HUMAN | Janus kinase 2 (JAK2) | Tyrosine-protein kinase JAK2 | Tyrosine-protein kinase JAK2 (808-1132) |
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| Type: | n/a |
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| Mol. Mass.: | 37984.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | 808-1132 aa of O60674 |
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| Residue: | 325 |
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| Sequence: | LFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCR
YDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKL
IMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE
NRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYEL
FTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWN
NNVNQRPSFRDLALRVDQIRDNMAG
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| BDBM228673 |
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| n/a |
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| Name | BDBM228673 |
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| Synonyms: | US10369153, Compound 104 | US9346810, 104 |
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| Type | Small Organic Molecule |
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| Emp. Form. | C18H18N6 |
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| Mol. Mass. | 318.3757 |
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| SMILES | CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N |
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| Structure | 
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