| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily V member 4 |
|---|
| Ligand | BDBM230241 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| Temperature | 310.15±n/a K |
|---|
| Ki | 590±n/a nM |
|---|
| IC50 | 1300±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Yukimasa, A Aromatic heterocyclic derivative having TRPV4-inhibiting activity US Patent US9340500 Publication Date 5/17/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transient receptor potential cation channel subfamily V member 4 |
|---|
| Name: | Transient receptor potential cation channel subfamily V member 4 |
|---|
| Synonyms: | TRPV4 | TRPV4_HUMAN | Transient receptor potential cation channel subfamily V member 4 (TRPV4) | VRL2 | VROAC |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 98290.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9HBA0 |
|---|
| Residue: | 871 |
|---|
| Sequence: | MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGP
GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDN
KRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRL
TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQT
ALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHI
VNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDS
NLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYD
LSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLC
AMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGV
NSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTG
TYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSC
RDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGE
TVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRV
DEVNWSHWNQNLGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDE
VVVPLDSMGNPRCDGHQQGYPRKWRTDDAPL
|
|
|
|---|
| BDBM230241 |
|---|
| n/a |
|---|
| Name | BDBM230241 |
|---|
| Synonyms: | US9340500, I-085 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H25F3N4O2 |
|---|
| Mol. Mass. | 458.4761 |
|---|
| SMILES | FC(F)(F)c1cccc(NC(=O)c2cc(nn2CCCN2CCOCC2)-c2ccccc2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
