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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neutrophil elastase | ||
| Ligand | BDBM232319 | ||
| Substrate/Competitor | US9346794, MeOSuc-Ala-Ala-Pro-Val-AMC | ||
| Meas. Tech. | Human Neutrophil Elastase Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 2.6±n/a nM | ||
| Comments | extracted | ||
| Citation |  Oost, T; Fiegen, D; Gnamm, C Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity US Patent US9346794 Publication Date 5/24/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neutrophil elastase | |||
| Name: | Neutrophil elastase | ||
| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 28532.38 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08246 | ||
| Residue: | 267 | ||
| Sequence: |
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| BDBM232319 | |||
| US9346794, MeOSuc-Ala-Ala-Pro-Val-AMC | |||
| Name | BDBM232319 | ||
| Synonyms: | US9346794, 23 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H24F3N5O4S | ||
| Mol. Mass. | 583.581 | ||
| SMILES | Cc1noc(C)c1-n1cc(C(=O)NCc2ccc(cc2)S(C)(=O)=NC#N)c(=O)c(c1C)-c1cccc(c1)C(F)(F)F |(1.91,-5.11,;.58,-5.88,;.1,-7.34,;-1.44,-7.34,;-1.91,-5.88,;-3.25,-5.11,;-.67,-4.98,;-.67,-3.44,;.67,-2.67,;.67,-1.13,;2,-.36,;2,1.18,;3.33,-1.13,;4.67,-.36,;4.67,1.18,;6,1.95,;6,3.49,;4.67,4.26,;3.33,3.49,;3.33,1.95,;4.67,5.8,;6,6.57,;4.67,7.34,;3.13,5.8,;1.59,5.8,;.05,5.8,;-.67,-.36,;-.67,1.18,;-2,-1.13,;-2,-2.67,;-3.33,-3.44,;-3.33,-.36,;-4.67,-1.13,;-6,-.36,;-6,1.18,;-4.67,1.95,;-3.33,1.18,;-4.67,3.49,;-3.33,4.26,;-6,4.26,;-4.67,5.03,)| | ||
| Structure | 
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