| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B2, mitochondrial |
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| Ligand | BDBM50028166 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cellular Inhibition Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 72±n/a nM |
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| Comments | extracted |
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| Citation |  Hartmann, R; Hille, U; Zimmer, C; Vock, CA; Hu, Q Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases US Patent US9394290 Publication Date 7/19/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Cytochrome P450 11B2, mitochondrial |
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| Name: | Cytochrome P450 11B2, mitochondrial |
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| Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
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| Type: | Protein |
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| Mol. Mass.: | 57582.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P19099 |
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| Residue: | 503 |
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| Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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| BDBM50028166 |
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| n/a |
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| Name | BDBM50028166 |
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| Synonyms: | CHEMBL934 | METYRAPONE | US9138393, Metyrapone | US9144538, Metyrapone | US9394290, MTP (metyrapone) |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14N2O |
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| Mol. Mass. | 226.2738 |
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| SMILES | CC(C)(C(=O)c1cccnc1)c1cccnc1 |
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| Structure | 
|
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