| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily V member 1 |
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| Ligand | BDBM245124 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Functional Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 20±n/a nM |
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| Comments | extracted |
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| Citation |  Allison, BD; Branstetter, BJ; Breitenbucher, JG; Hack, MD; Hawryluk, NA; Lebsack, AD; McClure, KJ; Merit, JE Tetrahydro-pyrimidoazepines as modulators of TRPV1 US Patent US9422293 Publication Date 8/23/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential cation channel subfamily V member 1 |
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| Name: | Transient receptor potential cation channel subfamily V member 1 |
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| Synonyms: | Capsaicin receptor | OTRPC1 | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 (TRPV1) | Trpv1 | Vanilloid Receptor 1 (TRPV1, VR1) | Vanilloid VR1 | Vanilloid receptor | Vanilloid receptor 1 (VRI/TRPV1) | Vanilloid receptor type 1-like | Vanilloid receptor type 1-like (TrpV1/Vr1) | Vr1 | Vr1l | osm-9-like TRP channel 1 |
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| Type: | Transient Receptor |
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| Mol. Mass.: | 94956.12 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | O35433 |
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| Residue: | 838 |
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| Sequence: | MEQRASLDSEESESPPQENSCLDPPDRDPNCKPPPVKPHIFTTRSRTRLFGKGDSEEASP
LDCPYEEGGLASCPIITVSSVLTIQRPGDGPASVRPSSQDSVSAGEKPPRLYDRRSIFDA
VAQSNCQELESLLPFLQRSKKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTIALLLDVA
RKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTK
GRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVD
NTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEP
ECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNR
LLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEIL
SVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVAS
MVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIE
DGKNNSLPMESTPHKCRGSACKPGNSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFI
ILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAF
RSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSG
RVSGRNWKNFALVPLLRDASTRDRHATQQEEVQLKHYTGSLKPEDAEVFKDSMVPGEK
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| BDBM245124 |
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| n/a |
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| Name | BDBM245124 |
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| Synonyms: | US9422293, 368 | US9422293, 369 | US9738649, Example 369 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27F6N5OS |
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| Mol. Mass. | 583.592 |
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| SMILES | CC1OCCC1Sc1nc2CCN(CCc2c(Nc2ccc(cc2C)C(F)(F)F)n1)c1ncccc1C(F)(F)F |
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| Structure | 
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