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TargetGlycogen synthase kinase-3 beta
LigandBDBM294093
Substrate/Competitorn/a
Meas. Tech.Enzyme Inhibition Assay
Temperature303.15±n/a K
IC50 5990±0.22 nM
Commentsextracted
Citation Martinez Gil, A; Ayuso-Gontan, CG; Palomo Ruiz, V; Perez Martin, C; Perez Fernandez, DI; Reyes Rodriguez, JA Heterocyclic GSK-3 allosteric modulators US Patent US9585879 Publication Date 3/7/2017
More Info.:Get all data from this article,  Assay Method
 
Glycogen synthase kinase-3 beta
Name:Glycogen synthase kinase-3 beta
Synonyms:GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:Enzyme
Mol. Mass.:46756.38
Organism:Homo sapiens (Human)
Description:P49841
Residue:420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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  Blast E-value cutoff:
BDBM294093
n/a
NameBDBM294093
Synonyms:1-Benzyl-7-chloro-N′dodecanoyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbohydrazide | US9585879, 62 | US9757369, 62
TypeSmall organic molecule
Emp. Form.C29H36ClN3O4
Mol. Mass.526.067
SMILESCCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2ccc(Cl)cc2n(Cc2ccccc2)c1=O
Structure
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