Reaction Details |
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Target | Serine/threonine-protein kinase mTOR [1360-2549] |
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Ligand | BDBM251633 |
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Substrate/Competitor | n/a |
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Meas. Tech. | LanthaScreen Kinase Activity Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 226±n/a nM |
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Comments | extracted |
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Citation | Pastor Fernández, J; Fernández-Capetillo Ruiz, O; Martínez González, S; Blanco Aparicio, C; Rico Ferreira, M; Toledo Lázaro, LI; Rodríguez Arísteguí, S; Murga Costa, M; Varela Busto, C; Lopez Contreras, AJ; Renner, O; Nieto Soler, M; Cebrián Muñoz, DA Chemical entities US Patent US9453031 Publication Date 9/27/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase mTOR [1360-2549] |
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Name: | Serine/threonine-protein kinase mTOR [1360-2549] |
Synonyms: | FRAP | FRAP1 | FRAP2 | MTOR | MTOR_HUMAN | RAFT1 | RAPT1 | Serine/threonine-protein kinase mTOR |
Type: | Enzyme |
Mol. Mass.: | 136306.16 |
Organism: | Homo sapiens (Human) |
Description: | aa 1360-2549 |
Residue: | 1190 |
Sequence: | LAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISI
NNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLG
RMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRD
THDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSEL
EEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASL
CGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQH
FVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAA
TEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAATAT
TTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNN
LQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQ
LLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRV
AILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLM
EAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELA
VPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVM
QLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKI
LLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTN
YTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRL
TRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGN
KRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQ
IINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW
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BDBM251633 |
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n/a |
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Name | BDBM251633 |
Synonyms: | US9453031, 70 |
Type | Small organic molecule |
Emp. Form. | C20H25N6O4S |
Mol. Mass. | 445.515 |
SMILES | CC(C)(c1nc(nc2N3CCOC[C@H]3COc12)[N]1=C(N)Nc2ccccc12)S(C)(=O)=O |r,c:20| |
Structure |
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