Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Tyrosine-protein kinase JAK1 | ||
Ligand | BDBM254987 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzyme Assay | ||
IC50 | 1.8±n/a nM | ||
Citation | Takahashi, K; Watanabe, T; Hayashi, K; Kurihara, K; Nakamura, T; Yamamoto, A; Nishimura, T; Kamiyama, T; Hidaka, Y Tricyclic pyrrolopyridine compound, and JAK inhibitor US Patent US9475813 Publication Date 10/25/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK1 | |||
Name: | Tyrosine-protein kinase JAK1 | ||
Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
Type: | Protein | ||
Mol. Mass.: | 133293.73 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P23458 | ||
Residue: | 1154 | ||
Sequence: |
| ||
BDBM254987 | |||
n/a | |||
Name | BDBM254987 | ||
Synonyms: | US9475813, 43 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H27N5O3S | ||
Mol. Mass. | 417.525 | ||
SMILES | CS(=O)(=O)NC[C@H]1CC[C@@H](CC1)N1CN(C2CC2)C(=O)c2cnc3[nH]ccc3c12 |r,wU:9.12,wD:6.5,(7.44,2.41,;6.1,3.18,;6.87,4.52,;5.33,4.52,;4.77,2.41,;3.44,3.18,;2.1,2.41,;.77,3.18,;-.56,2.41,;-.56,.87,;.77,.1,;2.1,.87,;-1.9,.1,;-3.23,.87,;-4.56,.1,;-5.9,.87,;-6.67,2.21,;-7.44,.87,;-4.56,-1.44,;-5.9,-2.21,;-3.23,-2.21,;-3.23,-3.75,;-1.9,-4.52,;-.56,-3.75,;.9,-4.22,;1.81,-2.98,;.9,-1.73,;-.56,-2.21,;-1.9,-1.44,)| | ||
Structure |