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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM254989 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Assay | ||
| IC50 | 2.1±n/a nM | ||
| Citation |  Takahashi, K; Watanabe, T; Hayashi, K; Kurihara, K; Nakamura, T; Yamamoto, A; Nishimura, T; Kamiyama, T; Hidaka, Y Tricyclic pyrrolopyridine compound, and JAK inhibitor US Patent US9475813 Publication Date 10/25/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
| ||
| BDBM254989 | |||
| n/a | |||
| Name | BDBM254989 | ||
| Synonyms: | US9475813, 45 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H22N6O | ||
| Mol. Mass. | 338.4069 | ||
| SMILES | O=C1NCN([C@H]2CC[C@H](CNCC#N)CC2)c2c1cnc1[nH]ccc21 |r,wU:5.4,wD:8.8,(-7.34,-1.54,;-6,-.77,;-6,.77,;-4.67,1.54,;-3.33,.77,;-2,1.54,;-2,3.08,;-.67,3.85,;.67,3.08,;2,3.85,;3.33,3.08,;3.33,1.54,;4.67,.77,;6,,;.67,1.54,;-.67,.77,;-3.33,-.77,;-4.67,-1.54,;-4.67,-3.08,;-3.33,-3.85,;-2,-3.08,;-.54,-3.56,;.37,-2.31,;-.54,-1.06,;-2,-1.54,)| | ||
| Structure | 
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