| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [866-1154] |
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| Ligand | BDBM128101 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | JAK1 Inhibition Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 6.6±0.7 nM |
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| Comments | extracted |
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| Citation |  Menet, CJ; Blanc, J Compound useful for the treatment of degenerative and inflammatory diseases US Patent US9505754 Publication Date 11/29/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK1 [866-1154] |
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| Name: | Tyrosine-protein kinase JAK1 [866-1154] |
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| Synonyms: | JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154) |
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| Type: | Protein |
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| Mol. Mass.: | 33185.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23458[866-1154] |
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| Residue: | 289 |
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| Sequence: | DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKE
IEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV
QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV
FWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLV
NTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
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| BDBM128101 |
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| n/a |
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| Name | BDBM128101 |
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| Synonyms: | US10206907, Compound 330 | US8796457, 1 | US9505754, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23N5O2 |
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| Mol. Mass. | 389.4503 |
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| SMILES | CC1(C)CN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 |
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| Structure | 
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