Reaction Details |
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Target | Glutaminyl-peptide cyclotransferase |
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Ligand | BDBM259924 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorometric Assays |
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pH | 8±n/a |
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Temperature | 303.15±n/a K |
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Ki | 14.9±n/a nM |
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Comments | extracted |
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Citation | Heiser, U; Buchholz, M; Sommer, R; Meyer, A; Demuth, H Inhibitors US Patent US9512115 Publication Date 12/6/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Glutaminyl-peptide cyclotransferase |
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Name: | Glutaminyl-peptide cyclotransferase |
Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 40877.05 |
Organism: | Homo sapiens (Human) |
Description: | Q16769 |
Residue: | 361 |
Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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BDBM259924 |
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n/a |
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Name | BDBM259924 |
Synonyms: | US9512115, 28 |
Type | Small organic molecule |
Emp. Form. | C20H17F4N3O2 |
Mol. Mass. | 407.3615 |
SMILES | CC(F)(F)CCc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F |r| |
Structure |
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