Reaction Details | |||
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Target | Leucine-rich repeat serine/threonine-protein kinase 2 | ||
Ligand | BDBM410702 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | in vitro peptide-based kinase assay | ||
IC50 | <100±n/a nM | ||
Citation | Hoflack, J; Blom, P; Lavergne, O; Gomez, S Macrocyclic LRRK2 kinase inhibitors US Patent US10377772 Publication Date 8/13/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Leucine-rich repeat serine/threonine-protein kinase 2 | |||
Name: | Leucine-rich repeat serine/threonine-protein kinase 2 | ||
Synonyms: | Dardarin | LRRK2 | LRRK2_HUMAN | Leucine-Rich Repeat Kinase 2 Protein (LRRK2) | Leucine-rich repeat serine/threonine-protein kinase 2 | Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) | PARK8 | ||
Type: | Protein | ||
Mol. Mass.: | 286113.20 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q5S007 | ||
Residue: | 2527 | ||
Sequence: |
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BDBM410702 | |||
n/a | |||
Name | BDBM410702 | ||
Synonyms: | US10377772, Compound N3 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H21FN6 | ||
Mol. Mass. | 352.4086 | ||
SMILES | Fc1ccc2NCCN3CCC(CC3)Nc3ccn4ncc(-c1c2)c4n3 |(4.89,1.33,;3.8,.24,;4.2,-1.25,;3.11,-2.34,;1.62,-1.94,;.53,-3.03,;-1.35,-4.91,;-3.55,-4.33,;-3.55,-2.79,;-4.89,-2.02,;-4.89,-.48,;-3.55,.29,;-2.22,-.48,;-2.22,-2.02,;-3.55,1.83,;-2.22,2.6,;-2.22,4.14,;-.89,4.91,;.45,4.14,;1.91,4.61,;2.82,3.37,;1.91,2.12,;2.31,.64,;1.22,-.45,;.45,2.6,;-.89,1.83,)| | ||
Structure |