| Reaction Details |
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 | Report a problem with these data |
| Target | CAM kinase, CDPK family TgCDPK1 |
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| Ligand | BDBM416597 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TgCDPK1 Enzymatic Inhibition Assay |
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| IC50 | 3.60±n/a nM |
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| Citation |  Hol, WG; Larson, ET; Maly, DJ; Van Voorhis, WC; Merritt, E; Ojo, KK Compositions and methods for treating toxoplasmosis, cryptosporidiosis and other apicomplexan protozoan related diseases US Patent US10307425 Publication Date 6/4/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| CAM kinase, CDPK family TgCDPK1 |
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| Name: | CAM kinase, CDPK family TgCDPK1 |
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| Synonyms: | TgCDPK1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57248.42 |
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| Organism: | Toxoplasma gondii (strain ATCC 50861 / VEG) |
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| Description: | n/a |
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| Residue: | 507 |
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| Sequence: | MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKG
SFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFED
KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL
LLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVIL
YILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISAR
DALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKEL
TAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNG
YIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSV
LSEVDKNNDGEVDFDEFQQMLLKLCGN
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|
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| BDBM416597 |
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| n/a |
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| Name | BDBM416597 |
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| Synonyms: | (3-((4-amino-3-(2-cyclopropoxyquinolin-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)oxetan-3-yl)methanol | US10307425, Example 64 | US10632122, Example 64 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22N6O3 |
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| Mol. Mass. | 418.4485 |
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| SMILES | Nc1ncnc2n(CC3(CO)COC3)nc(-c3ccc4nc(OC5CC5)ccc4c3)c12 |
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| Structure | 
|
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