Reaction Details |
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Target | Tyrosine-protein kinase BTK |
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Ligand | BDBM389995 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Btk Kinase Assay |
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IC50 | 505±n/a nM |
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Citation | Liu, D; Zhang, M; Hu, Q Aminopyridazinone compounds as protein kinase inhibitors US Patent US10323037 Publication Date 6/18/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase BTK |
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Name: | Tyrosine-protein kinase BTK |
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
Type: | Enzyme |
Mol. Mass.: | 76289.95 |
Organism: | Homo sapiens (Human) |
Description: | Q06187 |
Residue: | 659 |
Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
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BDBM389995 |
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n/a |
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Name | BDBM389995 |
Synonyms: | 4-amino-3-(4-phenoxyphenyl)-1- [(1-prop-2-enoylazetidin-3- yl)methyl]-6H-pyrrolo[2,3- d]pyridazin-7-one | US10323037, Example 12 | US9951077, 12 |
Type | Small organic molecule |
Emp. Form. | C25H23N5O3 |
Mol. Mass. | 441.4818 |
SMILES | Nc1n[nH]c(=O)c2n(CC3CN(C3)C(=O)C=C)cc(-c3ccc(Oc4ccccc4)cc3)c12 |
Structure |
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