| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] |
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| Ligand | BDBM420184 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MKNK1 Kinase High ATP Assay |
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| IC50 | 4.00±n/a nM |
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| Citation |  Giese, A; Klar, U; Graham, K; Kettschau, G; Sülzle, D; Lienau, P; Petersen, K; LeFranc, J; Schmidt, N Pyrazolopyridinamines as MKNK1 and MKNK2 inhibitors US Patent US10487092 Publication Date 11/26/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] |
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| Name: | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] |
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| Synonyms: | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] | MAP kinase signal-integrating kinase 1 (MNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)(T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] | MAP kinase-interacting serine/threonine-protein kinase 1 (T344D) | MKNK1 | MKNK1 (aa 1-424) T344D | MKNK1_HUMAN | MNK1 | MNK1a |
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| Type: | Protein |
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| Mol. Mass.: | 47416.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BUB5-2 with T344D |
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| Residue: | 424 |
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| Sequence: | MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES
PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR
CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA
HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPDPQVLQRNSSTMDLTLF
AAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSP
PTAL
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| BDBM420184 |
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| n/a |
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| Name | BDBM420184 |
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| Synonyms: | (7S)-4-[(6-Chloropyrazolo[1,5-a]pyridin-5-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-7-yl[(1R,4R)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]methanone | US10487092, Example 73 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24ClN7OS |
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| Mol. Mass. | 494.012 |
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| SMILES | CN1C[C@H]2C[C@@H]1CN2C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3Cl)c21 |r,TLB:0:1:7.6:4,8:7:2.1:4| |
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| Structure | 
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