| Reaction Details |
|---|
 | Report a problem with these data |
| Target | ADP-ribosylhydrolase ARH3 |
|---|
| Ligand | BDBM421539 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ARH3 Assay |
|---|
| IC50 | >16700±n/a nM |
|---|
| Citation |  McGonagle, AE; Jordan, AM; Waszkowycz, B; Hutton, CP; Waddell, ID; Hitchin, JR; Smith, KM; Hamilton, NM PARG inhibitory compounds US Patent US10508086 Publication Date 12/17/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| ADP-ribosylhydrolase ARH3 |
|---|
| Name: | ADP-ribosylhydrolase ARH3 |
|---|
| Synonyms: | ADP-ribose glycohydrolase ARH3 | ADP-ribosylhydrolase 3 | ADPRHL2 | ADPRS | ADPRS_HUMAN | ARH3 | O-acetyl-ADP-ribose deacetylase ARH3 | Poly(ADP-ribose) glycohydrolase ARH3 | [Protein ADP-ribosylarginine] hydrolase-like protein 2 | [Protein ADP-ribosylserine] hydrolase |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 38934.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NX46 |
|---|
| Residue: | 363 |
|---|
| Sequence: | MAAAAMAAAAGGGAGAARSLSRFRGCLAGALLGDCVGSFYEAHDTVDLTSVLRHVQSLEP
DPGTPGSERTEALYYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGV
VTVFKKLLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQL
THASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDAQSVLDARELGMEER
PYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIYCFLRCMEPDPEIPSAFNS
LQRTLIYSISLGGDTDTIATMAGAIAGAYYGMDQVPESWQQSCEGYEETDILAQSLHRVF
QKS
|
|
|
|---|
| BDBM421539 |
|---|
| n/a |
|---|
| Name | BDBM421539 |
|---|
| Synonyms: | 3-[(2,4-Dimethylthiazol-5-yl)methyl]-N-(1-methylcyclopropyl)-1-(5-methyl-1,3,4-thiadiazol-2-yl)indole-6-sulfonamide | US10508086, Example 129 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H23N5O2S3 |
|---|
| Mol. Mass. | 473.635 |
|---|
| SMILES | Cc1nnc(s1)-n1cc(Cc2sc(C)nc2C)c2ccc(cc12)S(=O)(=O)NC1(C)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
