| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 3 |
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| Ligand | BDBM421860 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| IC50 | <50±n/a nM |
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| Citation |  Huang, PQ; Kahraman, M; Slee, DH; Bunker, KD; Hopkins, CD; Pinchman, JR; Abraham, S; Sit, RK; Severance, DL Spirocyclic compounds US Patent US10493060 Publication Date 12/3/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 3 |
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| Name: | Mitogen-activated protein kinase 3 |
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| Synonyms: | ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | MAPK3 | MAPK3/MAPK7 | MK03_HUMAN | Mitogen-activated protein kinase | Mitogen-activated protein kinase 3 | PRKM3 |
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| Type: | Protein |
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| Mol. Mass.: | 43136.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | curated by PDB 4QTB |
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| Residue: | 379 |
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| Sequence: | MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP
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| BDBM421860 |
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| n/a |
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| Name | BDBM421860 |
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| Synonyms: | (S)-7-(2-(4-(4-(5-Fluoropyrimidin-2-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-2-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-2,7-diazaspiro[4.4]nonan-1-one | US10493060, Example 23 | US10525036, Example 23 |
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| Type | Small organic molecule |
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| Emp. Form. | C39H39FN8O3 |
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| Mol. Mass. | 686.7772 |
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| SMILES | CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)N1CC[C@]2(CCN(CC(=O)N3CCC(=CC3)c3ccc(cc3)-c3ncc(F)cn3)C2)C1=O |r,c:35| |
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| Structure | 
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