Reaction Details |
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Target | Mitogen-activated protein kinase 1 |
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Ligand | BDBM421861 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Kinase Assay |
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IC50 | <50±n/a nM |
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Citation | Huang, PQ; Kahraman, M; Slee, DH; Bunker, KD; Hopkins, CD; Pinchman, JR; Abraham, S; Sit, RK; Severance, DL Spirocyclic compounds US Patent US10493060 Publication Date 12/3/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 1 |
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Name: | Mitogen-activated protein kinase 1 |
Synonyms: | ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK |
Type: | Ser/Thr Protein Kinase |
Mol. Mass.: | 41392.76 |
Organism: | Homo sapiens (Human) |
Description: | P28482 |
Residue: | 360 |
Sequence: | MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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BDBM421861 |
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n/a |
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Name | BDBM421861 |
Synonyms: | (S)-2-(3-(6-Isopropoxypyridin-3-yl)-1H-indazol-5-yl)-7-(2-(4-(3-(1-methyl-1H-1,2,4-triazol-3-yl)bicyclo[1.1.1]pentan-1-yl)piperidin-1-yl)-2-oxoethyl)-2,7-diazaspiro[4.4]nonan-1-one | US10493060, Example 24 | US10525036, Example 24 |
Type | Small organic molecule |
Emp. Form. | C37H45N9O3 |
Mol. Mass. | 663.8117 |
SMILES | CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)N1CC[C@]2(CCN(CC(=O)N3CCC(CC3)C34CC(C3)(C4)c3ncn(C)n3)C2)C1=O |r| |
Structure |
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