Ki Summary

Reaction Details

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Target

Proto-oncogene Wnt-1

Ligand

BDBM385046

Substrate/Competitor

n/a

Meas. Tech.

The screening assay for Wnt activity

EC50

277±n/a nM

Citation

KC, SK; Mittapalli, GK; Hofilena, BJ; Marakovits, JT; Chiruta, C; Mak, CC; Cao, J Isoquinolin-3-yl carboxamides and preparation and use thereof US Patent US10508099 Publication Date 12/17/2019

More Info.:

Get all data from this article, Assay Method

Proto-oncogene Wnt-1

Name:

Proto-oncogene Wnt-1

Synonyms:

INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

41006.01

Organism:

Homo sapiens (human)

Description:

P04628

Residue:

370

Sequence:

MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPS
LQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRG
CRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLF
GREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLR
AVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCT
YSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNC
THTRVLHECL

BDBM385046

n/a

Name

BDBM385046

Synonyms:

US10287267, Compound 10 | US10508099, Compound 10 | US10556885, Compound 10 | US11174244, Compound 10 | US11673881, Compound 10

Type

Small organic molecule

Emp. Form.

C24H28FN5O

Mol. Mass.

421.5104

SMILES

Cn1cc(cn1)-c1ccc2cnc(NC(=O)[C@H]3CC[C@H](CN4CC(F)C4)CC3)cc2c1 |r,wU:19.20,wD:16.16,(-10.66,3.21,;-9.89,1.88,;-8.43,1.41,;-8.43,-.13,;-9.89,-.61,;-10.8,.64,;-7.09,-.9,;-7.09,-2.44,;-5.76,-3.21,;-4.43,-2.44,;-3.09,-3.21,;-1.76,-2.44,;-1.76,-.9,;-.43,-.13,;.91,-.9,;.91,-2.44,;2.24,-.13,;3.58,-.9,;4.91,-.13,;4.91,1.41,;6.24,2.18,;7.58,1.41,;7.98,-.08,;9.46,.32,;10.8,-.45,;9.06,1.8,;3.58,2.18,;2.24,1.41,;-3.09,-.13,;-4.43,-.9,;-5.76,-.13,)|

Structure