| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene Wnt-1 |
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| Ligand | BDBM385060 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | The screening assay for Wnt activity |
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| EC50 | 3700±n/a nM |
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| Citation |  KC, SK; Mittapalli, GK; Hofilena, BJ; Marakovits, JT; Chiruta, C; Mak, CC; Cao, J Isoquinolin-3-yl carboxamides and preparation and use thereof US Patent US10508099 Publication Date 12/17/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene Wnt-1 |
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| Name: | Proto-oncogene Wnt-1 |
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| Synonyms: | INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41006.01 |
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| Organism: | Homo sapiens (human) |
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| Description: | P04628 |
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| Residue: | 370 |
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| Sequence: | MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPS
LQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRG
CRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLF
GREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLR
AVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCT
YSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNC
THTRVLHECL
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| BDBM385060 |
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| n/a |
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| Name | BDBM385060 |
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| Synonyms: | US10287267, Compound 69 | US10508099, Compound 69 | US10556885, Compound 69 | US11174244, Compound 69 | US11673881, Compound 69 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20FN5O |
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| Mol. Mass. | 353.3934 |
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| SMILES | Cn1cc(cn1)-c1ccc2cnc(NC(=O)CN3CC[C@H](F)C3)cc2c1 |r| |
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| Structure | 
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